I doubt this is true, because Sony aren't looking to cast anyone yet, but let's discuss this. According to The Direct, Charlize Theron and Amy Adams are rumoured to play Madame Web. It may not be real and I don't think it is as Sony are seemingly not going to cast anybody (I'll assume they're planning to cast once a film/TV Show finishes writing AND goes into production). But let's discuss! Would these be good castings? Let me know!